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Joel S. Ross, MD |
MD FACP AGSF CMD CPI |
President and Founder |
Memory Enhancement Center |
of America, Inc. |
4 Industrial Way West, 2nd Floor |
Eatontown, New Jersey 07724 |
732.571.1535 |
A New Way to Look at Alzheimer’s
By Joel Ross | November 23, 2011
This post written below by Ms. Walton gets to probably the crux of AD: low clearance of normally produced a-beta amyloid. Randy Bateman MD, a foremost expert in this field showed similar results.
By Alice G. Walton
Nov 19 2011, 1:55 PM ET 2
The prevailing theory suggests the destructive buildup of plaques occurs when cells secrete too much beta-amyloid peptide, but a new study argues the problem is clearance, not production
In recent years, researchers have made a number of major advances in understanding the origins of Alzheimer’s. But a new study shows that however much we know, new research can change the game.
MORE FROM THE DOCTOR:
An Over-Abundance of Neurons
Wider Waists and Colon Cancer
Preschoolers Learning Language
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The prevailing theory of Alzheimer’s suggests that the destructive buildup of plaques outside brain cells occurs because brain cells secrete too much beta-amyloid peptide, the precursor to plaques. Recent studies have suggested that the problem in Alzheimer’s lies not in the brain’s production of the plaques, but in its clearance of them.
However, there may be even more to the story than what we knew up until now. New research shows that brain cells may actually have trouble secreting beta-amyloid peptide that has built up inside the cells, rather than secreting too much. The team showed that beta-amyloid builds up within the neuron first, presumably because the neuron has trouble pushing it out. And it’s this early step — the internal buildup of the beta-amyloid — that may be the cornerstone of the disease.
When brain cells get clogged with beta-amyloid, their function may be impaired. There is some level at which the cell can no longer hold the beta-amyloid that accumulates within it, so the membrane may burst, expelling beta-amyloid peptide into the extracellular space. It is at this point that beta-amyloid can turn into full-blown plaques outside the cells.
Study author Gunnar Gouras suggests that pharmaceutical companies may need to take the findings into account as they design Alzheimer’s medications. “The many investigators and pharmaceutical companies screening for compounds that reduce secreted beta-amyloid have it the wrong way around. The problem is rather the opposite, that it is not getting secreted. To find the root of the disease, we now need to focus on this critical intracellular pool of beta-amyloid.”
The reason for the cells’ inability to rid themselves of beta-amyloid is unclear, but author Davide Tampellini says that it is “probably because the cell’s metabolism and secretion pathways are disrupted in some way, leading beta-amyloid to be accumulated inside the cell instead of being secreted naturally.” Future studies will need to look into the exact reasons the pathways begin to malfunction. This, finally, may get to the root cause of why Alzheimer’s develops at all.
The study was carried out at Weill Cornell Medical College and published in the October 26, 2011, online issue of the Journal of Neuroscience.
Image: Lightspring/Shutterstock.
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This article originally appeared on TheDoctorWillSeeYouNow.com, an Atlantic partner site.
Topics: Uncategorized | No Comments »
Banner Institute Forges New Directions
By Joel Ross | November 19, 2011
I have had the privilege of meeting Dr. Tariot one of the directors of the Banner Institute in Arizona. A more passionate man devoted to dementia prevention is only equaled perhaps by yours truly.
Together I believe his Banner Institute in collaboration/cooperation with my Memory Enhancement Centers will forge new alliances to prevent or delay the symptoms of dementia due to Alzheimer’s Disease.
Visit his website at http://www.bannerhealth.com
Stay tuned for a first of its kind “prevention” study coming from the Memory Enhancement Centers of America. It will be starting if all goes well April 2012.
Topics: Uncategorized | No Comments »
Being fat may make you high risk for dementia
By Joel Ross | October 17, 2011
(800) 829-0422 www.johnshopkinshealthalerts.com | Johns Hopkins Health Bookstore | Email this to a friend
Research on Abdominal Fat and Dementia
Gaining weight, especially around the midsection, has been associated with a number of health conditions, including diabetes, heart disease and cancer. New research suggests that you can add shrinking brain size — a hallmark of Alzheimer’s disease and dementia — to that list.
Using data collected from 733 healthy participants (average age 60) in the Framingham Offspring cohort, investigators looked at the associations among body mass index (BMI), waist circumference, waist-to-hip ratio, amount of subcutaneous and visceral (abdominal) fat and four different magnetic resonance imaging (MRI) based measurements of brain volume.
Researchers discovered that although all of the assessments of weight were linked with a reduction in brain volume to some degree, the link was strongest between abdominal fat and decreased brain volume. This association was independent of BMI and measurements of insulin resistance. The study was reported in the Annals of Neurology (online edition, May 20, 2010).
Take away: This finding sheds some light on the mechanisms that underlie the association between weight gain and dementia, which is still not well understood. People who are concerned about dementia may want to take steps, such as exercise and diet, to lower their amount of abdominal fat.
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A valuable resource that belongs in the home health library of all families concerned about Alzheimer’s
A dramatic increase in the number of people affected by Alzheimer’s disease has heightened the urgency of research into Alzheimer’s and other dementias. The Memory White Paper brings you state-of-the-art information on how to tell the difference between Alzheimer’s, another form of dementia or ordinary age-related memory loss and the best ways to keep your memory sharp as you get older. You will also learn about important new research in identifying, treating and preventing memory disorders, as well as new drugs for Alzheimer’s and other dementias that can help slow memory decline.
Read more or order …
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Interview – Smarter Heart show on WOBM
By admin | September 29, 2011
Joel S. Ross MD FACP AGSF CMD CPI
President/Founder/CEO
Topics: Audio / Interviews | No Comments »
Insulin may help Alzheimer’s Disease patients
By Joel Ross | September 18, 2011
Insulin may slow Alzheimer’s, study finds
Inhaling it through the nose twice daily seems to slow symptoms of memory loss. More study is needed, but researchers are encouraged.
Inhaling a concentrated cloud of insulin through the nose twice a day appears… (Katja Heinemann / HBO)
September 13, 2011|By Melissa Healy, Los Angeles Times
Inhaling a concentrated cloud of insulin through the nose twice a day appears to slow — and in some cases reverse — symptoms of memory loss in people with early signs of Alzheimer’s disease, a new pilot study has found.
The study involved only 104 people and is considered very preliminary. But it suggests that a safe, simple and cheap measure that boosts flagging metabolism in key areas of the brain could hold off or possibly derail the progression of the devastating neurological disorder in its early stages. The results were published online Monday by the journal Archives of Neurology.
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